If you come from the Windows Operating System ecosystem, a scroll of mouse wheel downwards results in a scroll-down and a scroll of mouse wheel up does scroll-up. The first thing you would notice when you attach a wheel mouse the behavior is the exact opposite of it.
In order to change the mouse scroll directions, follow the below steps,
- Click on the Apple Logo on the Menu Bar,
- Select "System Preferences...",
- Search Mouse and click on the icon,
- Uncheck Scroll direction Natural.

The above example is demonstrated on macOS Big Sur on M1 Macbook Air, but should be the same for most of the earlier versions.
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