If you have a lot of files open in Notepad++ as multiple tabs and you want to save all of them at once, you can make use of the keyboard shortcut Control + Shift + S.
You can also achieve the same by going to Menu: File -> Save All...
Before files are saved you will see a warning.
Are you sure you want to save all modified documents?
Choose Always Yes" if you don't want to see this dialog again.
You can re-activate this dialog in Preferences later.
If you select Yes, all files will be saved at once.

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